Couples should thoroughly consider the question of blood group compatibility before planning their pregnancy especially if that’s their first baby.
This post will provide you with all essential information about blood group compatibility for marriage.
If you worry about a negative or a positive blood group matching blood group and genotype for marriage, you have to bear in mind that matching blood types for couples is a lot like matching blood with donors and receivers.
However, a lot of people still think that Rh-negative men match only Rh-negative women. It should be mentioned that Rh-negative women are more numerous than men.
It is also known that Rh incompatibility may lead to erythroblastosis fetalis (Hemolytic disease of the newborn-HDN). As a result, fetal RBC can get destroyed and the baby receives severe anaemia or serious jaundice. In some cases, the fetus might even die because of heart failure. This is caused by antigen-antibodies reaction.
This is why Rh+ve men should not have babies with Rh-ve ladies.
Newborn babies suffering from erythroblastosis fetalis might need exchange transfusion. Their blood test is taken checking their bilirubin levels. Excess levels of bilirubin may cause severe brain damage (called bilirubin encephalopathy).
Such babies are apathetic and slow at sucking. Their fontanelles will often be bulging.
These problems aggravate with each subsequent pregnancy. However, incompatibilities in ABO blood types never lead to erythroblastosis fetalis.
Contemporary medicine can prevent erythroblastosis fetalis through applying Rh0 (D) immune globulin at 28 wk gestation and within 72 h of pregnancy termination to the mother.